Drug-Induced Diabetes Insipidus: Has Its Importance Been Diluted?
In drug-induced diabetes insipidus, urine cannot be concentrated despite adequate secretion of antidiuretic hormone (vasopressin). Lithium used for the treatment of affective disorders is the most common cause of this serious adverse effect, which can lead to dehydration and aggravation of lithium intoxication. Other classes of drug, such as antibacterials and antineoplastics, are also associated with this condition. Treatment includes eliminating the causative agent and controlling water balance. In severe cases, urinary output can be reduced using diuretics or NSAIDs. The risks associated with lithium-induced diabetes insipidus can be reduced by keeping doses as low as possible and informing patients about the condition.
In drug-induced diabetes insipidus, urine cannot be concentrated despite adequate secretion of antidiuretic hormone (vasopressin). Lithium used for the treatment of affective disorders is the most common cause of this serious adverse effect, which can lead to dehydration and aggravation of lithium intoxication. Other classes of drug, such as antibacterials and antineoplastics, are also associated with this condition. Treatment includes eliminating the causative agent and controlling water balance. In severe cases, urinary output can be reduced using diuretics or NSAIDs. The risks associated with lithium-induced diabetes insipidus can be reduced by keeping doses as low as possible and informing patients about the condition.
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